FAB-BASED INHIBITORS REVEAL UBIQUITIN INDEPENDENT FUNCTIONS FOR HIV VIF NEUTRALIZATION OF APOBEC3 RESTRICTION FACTORS.

Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors.

The lentiviral protein Viral Infectivity Factor (Vif) counteracts the antiviral effects of host APOBEC3 (A3) proteins and contributes to persistent HIV infection.Vif targets A3 restriction factors for ubiquitination and proteasomal degradation by recruiting them to a multi-protein ubiquitin E3 ligase complex.Here, we describe a degradation-independ

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The Open Limit Point Compactness

In this paper, we gave a new topological concept and we called it the open limit point compactness.We have proved that each of the compactness, and the limit point compactness is stronger than moen s73004srs of the open limit point compactness., that is, compactness implies open limit point compactness, also limit point compactness implies open lim

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